Pharmaceutical Ingredients Norfloxacin Base

Norfloxacin, a type of broad-spectrum antibiotic, belongs to the third-generation quinolone class.
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Description

Norfloxacin is a broad-spectrum antibacterial agent with strong bactericidal activity, especially against Gram-negative bacteria. It has a lower minimum inhibitory concentration (MIC) compared with commonly used anti-Gram-negative drugs and shows no cross-resistance with other fluoroquinolones or antibiotics.

 

Specification

 

CAS No. : 70458-96-7

EINECS: 274-614-4

Package : 25KG/DRUM

Brand: TOPINCHEM®

Origin: CHINA

Formula: C16H18FN3O3

Minimum Order: 20KG

 

Analysis content

Specification

Analysis results

Appearance

White or pale yellow, hygroscopic, photosensitive, Crystalline powder

Meet the requirement

Solubility

very slightly soluble in water, slightly soluble in acetone, and in ethanol(96 per cent)

Meet the requirement

Identificatiom

Comparison: norfloxacin CRS

 

Appearance of the solution

≤Sol.II

Meet the requirement

≤B

Meet the requirement

Impurities E

≤0.15%

0.09%

Impurities K

≤0.15%

0.03%

Unspecified Impurities

≤0.10%

0.01%

Total impurities

≤0.50%

0.19%

Sulphated ash

≤0.1%

0.05%

Loss on drying

≤1.0%

0.53%

Heavy Metak

≤15ppm

<15ppm

Assay

98.0%~102.0%(The dried substance)

99.70%

 

Application

51

Norfloxacin is primarily used to treat urinary tract and intestinal infections caused by susceptible bacteria. It is also employed in the management of gonorrhea, typhoid fever, and other Salmonella infections.

 

 

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