Chlortetracycline hydrochloride is a broad-spectrum tetracycline antibiotic effective against Gram-positive and Gram-negative bacteria, as well as Rickettsia, Chlamydia, Mycoplasma, spirochetes, Actinomyces, and certain protozoa.
Characteristics
Appearance: Golden-yellow crystalline powder, bitter taste, odorless
Stability: Stable in air but gradually darkens on light exposure
Solubility: Very slightly soluble in water, soluble in saline solutions, sparingly soluble in ethanol, insoluble in most organic solvents
Specification
CAS No. : 57-62-5
EINECS: 200-341-7
Package : 25KG/DRUM
Brand: TOPINCHEM®
Origin: CHINA
Formula: C22H23ClN2O8
Minimum Order: 500KG
|
NO. |
TESTS |
SPECIFICATIONS |
RESULTS |
|
1 |
Appearance |
Yellow powder |
Conforms |
|
2 |
Identification |
||
|
2.1 |
A(Current Ph.Eur.2.2.27) |
Thin-Layer Chromatography |
Positive |
|
2.2 |
B(Current Ph.Eur.0173) |
The colour becomes brownish |
Positive |
|
2.3 |
C(Current Ph.Eur.2.3.1) |
It gives the reaction (a) of chlorides |
Positive |
|
2.4 |
D(Current Ph.Eur.2.2.29) |
Liquid chromatography |
Positive |
|
3 |
pH(Current Ph.Eur.2.2.3) |
2.3~3.3 |
2.6 |
|
4 |
SpecificOpticalRotation(CurrentPh.Eur.2.2.7) |
-250°~-235(anhydrous substance) |
-245° |
|
5 |
Absorbance(Current Ph.Eur.2.2.25) |
≤0.40,460nm |
0.28 |
|
6 |
Related substances(Current Ph.Eur.2.2.29) |
||
|
6.1 |
Impurity A (4-epichlortetracycline) |
≤4.0% |
1.56% |
|
6.2 |
Impurity B(demeclocycline) |
≤1.0% |
0.07% |
|
6.3 |
Impurity E(4-epidemethylchlortetracycline) |
≤1.0% |
0.70% |
|
6.4 |
Impurity J(anhydrotetracycline) |
≤0.3% |
0.09% |
|
6.5 |
Impurity D(4-epitetracycline) |
≤0.2% |
0.08% |
Application
It is primarily used in poultry for the prevention and treatment of chronic respiratory disease and colibacillosis. It shows strong efficacy against Gram-positive bacteria such as Staphylococcus, Bacillus anthracis, Streptococcus hemolyticus, Clostridium tetani, and other Clostridium species, as well as Gram-negative bacteria including Escherichia coli, Salmonella, Brucella, and Pasteurella.
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